Chromosome 15q11-q13 duplications in four families. A. Schematic representation of the region, highlighting the extent of the duplications in the four families (blue lines), the localization of the MLPA probes (red triangles) and FISH probes (yellow ovals) used, and the genes within the interval along with their orientation (green arrows). B. MLPA peak ratio for 15q11-13 (red and green) and control (blue) MLPA test probes in Family 1 individuals AU010604 (left) and AU010602 (right). Red, probes with peak ratios > 1.3; green, probes with peak ratios <= 1.3. In the left panel, the green rectangle with a peak ratio of ~1 corresponds to APBA2. C. Segregation of the duplications in the four families.
Cai et al. BMC Medical Genomics 2008 1:50 doi:10.1186/1755-8794-1-50