Table 1

Most highly deregulated transcripts in mammary gland induced by bexarotene treatment on each transgenic mice mammary cancer model (Fold change ≥ 7; p < 0.01).

Tag

Gene

Description

Entrez Gene

Fold Change*


p53-null

GTTTGCTGTA

Serpinb6a

Serine (or cysteine) peptidase inhibitor

20719

17.0

AGTCTCGAGG

Slc1a5

Solute carrier family 1

20514

12.0

GGTTTGGGGG

Jup

Junction plakoglobin

16480

11.0

TGCGTGCTGG

Timp2

Tissue inhibitor of metalloproteinase 2

21858

11.0

TTGAAATTAC

BC061494

CDNA sequence

381832

11.0

GATTTCTTTG

Gpc3

Glypican 3

14734

10.0

TAACCAAAAA

Itgb4

Integrin beta 4

192897

10.0

CCCAGTCCCT

Ltbp4

Latent transforming growth factor bindin. prot. 4

108075

8.0


GACTCTATAT

Csn2

Casein beta

12991

-15.0

CAATAAAACA

Sar1b

SAR1 gene homolog B (S. Cerevisiae)

66397

-11.0

GCAGCGATTC

Nme2

Expressed in non-metastatic cells 2

18103

-10.0

TGTTCTATGG

Laptm5

Lysosomal-associated protein transmembrane 5

16792

-9.0

GTGTTTTGCT

AI451557

Expressed sequence

102084

-9.0

CTAGGTGGTG

Glycam1

Glycosylation dependent cell adhesion molecule 1

14663

-8.8

TAAAGTCAAT

Muc15

Mucin15

269328

-8.0

TCAGAGTGAG

Igh-6

Immunoglobulin heavy chain 6

16019

-7.5


MMTV-erbB2

AGACCCTGTC

Pnpla3

Patatin-like phospholipase domain containing 3

116939

44.0

TATGAGATAG

Timm9

Translocase of inner mitochondrial membrane 9

30056

15.0

AGCCCTCGGA

Acads

Acyl-Coenzyme A dehydrogenase

11409

12.0

ACCGGGCTGG

Elovl6

ELOVL family member 6

170439

12.0

TGACAGAAGA

Tnnc2

Troponin C2

21925

10.0

TCTCTCAGTC

Anxa5

Annexin A5

11747

9.0

CACAGAACCA

0610031J06

RIKEN cDNA 0610031J06 gene

56700

7.0

CCTGCAGCAG

2900073H19

RIKEN cDNA 2900073H19 gene

68205

7.0


GCCACTTAAG

Cd79a

CD79A antigen (immunoglubulin-associated alpha)

12518

-15.0

AGCCATCATA

2610042O14

RIKEN cDNA 2610042O14 gene

66460

-13.0

AGCGAAATAA

Gmfg

Glia maturation factor gamma

63986

-11.0

CTGCAGCCTA

Stx5a

Syntaxin 5A

56389

-11.0

TTACAAGCCT

Cks1b

CDC28 protein kinase 1b

54124

-10.0

GTGGACTCAA

Ifitm1

Interferon induced transmembrane protein 1

68713

-10.0

CATAGTTTAA

Nol7

Nucleolar protein 7

70078

-10.0

AAGTTCTTCA

Csn1s2a

Casein alpha s2-like A

12993

-9.0


C3(1) SV40 T-antigen

AGCAGTGCTT

Ccdc3

Coiled-coil domain containing 3

74186

13.0

CAGTTTGTAA

Pdha1

Pyruvate dehydrogenase E1 alpha 1

18597

10.0

AATGTGTATG

Abca8a

ATP-binding cassette sub-family A (ABC1)

217258

9.0

ATTCCCTGTT

Krtap8-1

Keratin associated protein 8-1

16703

8.0

CCGAAAAAAA

Pink1

PTEN induced putative kinase 1

68943

7.0

ACTCTAAAAA

Tmem55b

Transmembrane protein 55b

219024

7.0

CTGTAGTGTC

Ltf

Lactotransferrin

17002

7.0

CTGTCCAAGG

Bhlhb2

Basic helix-loop-helix domain containing class B2

20893

7.0


GAAAATAAAA

Fndc3a

Fibronectin type III domaing containing 3a

319448

-20.0

TAAATTAAGA

Hexb

Hexosaminidase B

15212

-16.0

TTAGAAGTGA

Sav1

Salvador homolog 1 (Drosophila)

64010

-15.0

GGGGGTGAGG

Hisppd1

Histidene acid phosphatase domain containing 1

227399

-15.0

TAACAAAGGA

Ahcyl1

S-adenosylhomocysteine hydrolase-like 1

229709

-14.0

GATTAAAACA

4931406I20

RIKEN cDNA 4931406I20 gene

66743

-11.0

TTAACACTGT

Rab35

RAB35, member RAS oncogene family

77407

-10.0

CAGATTAAAA

Gbp6

Guanylate binding protein 6

229900

-9.0


*Up-regulated transcripts in bexarotene treatment are represented by positive fold changes and down-regulated transcripts are represented by negative fold changes.

Abba et al. BMC Medical Genomics 2008 1:40   doi:10.1186/1755-8794-1-40

Open Data