|
Summary of common recurrently amplified regionsa, b |
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| Cytogenetic region |
Mb start position (BAC) |
Mb end position (BAC) |
Size (Mb) |
Genesc |
No. cases |
|
|
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| 1p34 |
39.27 (RP11-528I12) |
40.26 (RP11-747C18) |
1.0 |
MACF1, PABPC4, TRIT1 |
3 (8%) |
| 1q23 |
157.00 (RP11-735D24) |
157.81 (RP11-812N5) |
0.8 |
- |
4 (11%) |
| 2p25 |
9.42 (RP11-360P14) |
10.34 (RP11-360P14) |
0.9 |
3 (8%) |
|
| 3p25 |
10.20 (RP13-635L13) |
12.52 (RP11-738A2) |
2.3 |
TATDN2, SEC13L1, VGLL4 |
3 (8%) |
| 6p22 |
20.07 (RP11-345F7) |
22.08 (RP11-630B10) |
1.8 |
8 (21%) |
|
| 8q22 |
101.23 (RP11-321E7) |
102.99 (RP11-811I18) |
1.8 |
5 (13%) |
|
| 10q22 |
76.24 (RP11-368I19) |
78.49 (RP11-272P2) |
2.3 |
MYST4 |
3 (8%) |
| 11q13 |
69.07 (CTD-2192B11) |
70.20 (CTD-2011L13) |
1.1 |
CCND1, ORAOV1, PPFIA1, CTTN |
3 (8%) |
| 16p13 |
10.59 (RP11-78D17) |
12.84 (RP11-310B24) |
2.3 |
NUBP1, DEXI, TXNDC11, ZC3H7A, RSL1D1, GSPT1 |
3 (8%) |
|
aMapping data is based on the UCSC genome browser (May 2004 freeze), and listed regions represent core amplicons. bOnly regions amplified in at least 3 cases are listed. cGenes that showed top ranking expression levels when genomically amplified. More detailed data for the 6p22, 8q22, and for 2p25 is given in Additional file 3. | |||||
Heidenblad et al. BMC Medical Genomics 2008 1:3 doi:10.1186/1755-8794-1-3 |
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