Table 3

Comparative transcriptomic analysis of normal human epithelial melanocytes to thin primary cutaneous and metastatic melanoma samples

    Fold Higher Expression in Melanoma

    Fold Lower Expression in Melanoma


    Gene Symbol

    NHEM c/t MIS/Thin

    Gene Symbol

    NHEM c/t Metastatic Melanoma

    Gene Symbol

    NHEM c/t MIS/Thin

    Gene Symbol

    NHEM c/t Metastatic Melanoma


KRT14

6787

GJA1

759

MME

106

MAP4

20

GJA1

5929

SEPP1

338

CITED1

77

OCA2

10

EHF

5487

KRT14

306

GDF15

64

TRIM7

7

SCEL

3931

MAGEA2

301

PAEP

47

CITED1

6

CLCA2

3689

TRAG3

242

RPEL1

45

TRPM4

6

S100A7

3609

EHF

193

HES6

43

MME

5

KRTDAP

3416

S100A9

160

ESDN

37

TRAP150

5

DSC1

2782

S100A7

129

QPRT

35

FER1L3

4

GJB6

2576

SCEL

126

OCA2

19

QPRT

4

CXCL14

2484

SLC22A3

125

RENBP

17

KLF8

4

LOR

2308

EPHA3

124

NR4A3

16

RPEL1

4

KRT6A

1989

KRTDAP

121

Siat7c

16

PACE4

4

PKP1

1835

S100A8

120

C6orf168

15

HPCAL1

4

SERPINB3

1778

ZIC1

119

BCL2A1

14

ACTR1A

4

S100A9

1768

CXCL14

118

NTT73

14

MET

3

KRT15

1545

IL18

108

PSCD3

14

RAB32

3

GATA3

1347

PRAME

102

HPCAL1

13

TYR

3

PPL

1339

MAGEA6

94.7

MET

12

IRF6

3

IMUP

1250

PLCB4

88

ALS2CR3

12

GDF15

3

ICEBERG

1123

CLCA2

87

PTPLA

12

HINT3

3

KRT6B

1114

GJB6

85

TBC1D7

11

SLC30A1

3

CSTA

693

MAGEA3

84

OA1

11

TRPV2

3

CST6

687

MMP19

59

TYR

11

RSN

3


NOTE: Abbreviations: NHEM: Normal Human Epithelial Melanocytes, c/t: Compared to, MIS, melanoma-in-situ, Thin, thin melanomas < 1.0 mm in Breslow's thickness

Riker et al. BMC Medical Genomics 2008 1:13   doi:10.1186/1755-8794-1-13

Open Data