Table 1

Differential gene expression between metastatic melanoma and non-metastatic cutaneous tumors

    Gene symbol

    Increase in metastatic melanoma relative to

    Gene symbol

    Decrease in metastatic melanoma relative to

MIS/Thin

BCC/SCC/MIS/Thin

MIS/Thin

BCC/SCC/MIS/Thin


MAGEA3/A6/A12

125/119/57

27/25/29

CALML5

193

228

MAGEA1/A2/A5

24/57/10

13/31/6

DSC1/3

186/64

198/71

CSAG2

76

36

PKP1

166

240

TRIM51

51

35

CLCA2

162

177

GDF15

30

47

DSG1/3

160/73

178/119

GYPC

18

14

LY6D

143

147

SPP1

15

7

SERPINB3/B5/B7

111/199/106

184/227/144

KIFC1

15

3

C19orf33

122

135

RGS20

14

14

FLG

112

112

C1orf90

13

15

KRT5/16/17

49/111/105

62/196/274

BCL2A1

12

12

KLK7/8/10/11

99/23/27/65

112/32/81/83

SOX5

15

8

LOR

95

98

SLC16A4

12

29

LGALS7

84

89

AKT3

11

9

CST6

82

56

PEG10

11

10

TRIM29

79

119

BUB1

14

3

SFN

77

125

RASGRF1

8

12

ASAH3

69

56

MMP14

8

6

GATA3

63

54

SPRED1

6

4

CBLC

60

64

GPR19

6

5

RAB25

59

78

CDK2

6

7

S100A14/A7/A7L1

27/57/21

44/60/82

HOXA10

3

4

ICEBERG

52

48

HOXB6/7/9

4/5/3

6/7/3

IVL

50

76

HEY1

7

16

ELOVL4

38

34

DUSP4

8

10

CXCL14

36

37

DUSP6

8

6

FOXN1

33

34

CDC45L

7

8

AQP3

29

31

CDC6

9

4

TP73L

29

48

RRM2

6

4

MUC15

25

21

TYMS

4

3

RORA

24

22

BIRC5

4

2

CD24

19

38


The initial statistical analysis addressed the question of whether there were genes differentially expressed (increased or decreased) between primary cancers (BCC/SCC/PCM) and metastatic cancers (metastatic melanoma). Column 1 (MIS/thin) are comprised of only such lesions, while column 2 (BCC/SCC/MIS/Thin) is comprised of all 4 histologic subtypes. All of the annotated genes listed above had a > 2-fold up- or down-regulation in gene expression with the full names of each gene, accession number and gene identification provided in supplementary table 1. Abbreviations: MIS, melanoma-in-situ, BCC, basal cell carcinoma, SCC, squamous cell carcinoma, Thin, thin melanomas < 1.5 mm in Breslow's thickness.

Riker et al. BMC Medical Genomics 2008 1:13   doi:10.1186/1755-8794-1-13

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