Table 3

Genes downregulated in palmar fascia fibroblasts obtained from Dupuytren's Contracture using Illuminaâ„¢ Platform.

Gene ID

Gene Name

Fold Change


1.

NM_005807

Homo sapiens proteoglycan 4 (PRG4), mRNA.

0.08

2.

NM_020299

Homo sapiens aldo-keto reductase family 1, member B10 aldose reductase) (AKR1B10), mRNA.

0.15

3.

NM_145176

Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 12 (SLC2A12), mRNA.

0.18

4.

NM_001831

clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) (CLU), transcript variant 1

0.21

5.

NM_012168

F-box protein 2 (FBXO2), mRNA

0.21

6.

NM_139125

Homo sapiens mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 2, mRNA.

0.22

7.

NM_000691

Homo sapiens aldehyde dehydrogenase 3 family, memberA1 (ALDH3A1), mRNA

0.22

8.

NM_178127

Homo sapiens angiopoietin-like 5 (ANGPTL5), mRNA

0.23

9.

NM_004000

chitinase-3-like 2 (CHI3L2)

0.22

10.

NM_005410

Homo sapiens selenoprotein P, plasma, 1 (SEPP1), mRNA

0.23

11.

NM_001996

Homo sapiens fibulin 1 (FBLN1), transcript variant C, mRNA

0.24

12.

NM_015714

Homo sapiens G0/G1switch 2 (G0S2), mRNA

0.24

13.

NM_021146

angiopoietin-like factor (CDT6)

0.24

14.

NM_006486

Homo sapiens fibulin 1 (FBLN1), transcript variant D, mRNA

0.25

15.

NM_000956

Homo sapiens prostaglandin E receptor 2 (subtype EP2), 53kDa (PTGER2), mRNA

0.26

16.

NM_005525

Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1, mRNA

0.28

17.

NM_173640

Homo sapiens R-spondin homolog (Xenopus laevis) (RSPO1), transcript variant 2, mRNA.

0.30

18.

NM_001801

cysteine dioxygenase type1 (CDO1)

0.30

19.

XM_352750

Homo sapiens collagen, type XIV, alpha 1 (undulin) (COL14A1), mRNA.

0.31

20.

NM_002150

Homo sapiens 4-hydroxyphenylpyruvate dioxygenase (HPD), mRNA

0.33

21.

NM_001855

Homo sapiens collagen, type XV, alpha 1 (COL15A1), mRNA.

0.33

22.

XM_166300

Homo sapiens absent in melanoma 1 (AIM1), mRNA

0.36

23.

NM_005627

Homo sapiens serum/glucocorticoid regulated kinase (SGK), mRNA

0.36

24.

NM_016564

Homo sapiens cell cycle exit and neuronal differentiation 1 (CEND1), mRNA.

0.38

25.

NM_133371

Homo sapiens myozenin 3 (MYOZ3), mRNA

0.40

26.

NM_001290

Homo sapiens LIM domain binding 2 (LDB2), mRNA.

0.41

27.

NM_003383

Homo sapiens very low density lipoprotein receptor (VLDLR), transcript variant 1, mRNA.

0.43

28.

NM_005631

Homo sapiens smoothened homolog (Drosophila) (SMO), mRNA

0.43

29.

NM_014746

Homo sapiens ring finger protein 144 (RNF144), mRNA

0.44

30.

NM_000636

superoxide dismutase 2, mitochondrial (SOD2)

0.45

31.

NM_000690

aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), nuclear gene encoding mitochondrial protein, mRNA.

0.48

32.

NM_002222

Homo sapiens inositol 1,4,5-triphosphate receptor, type 1 (ITPR1), mRNA

0.48

33.

NM_012329

Homo sapiens monocyte to macrophage differentiation-associated (MMD), mRNA.

0.50

34.

NM_000861

Homo sapiens histamine receptor H1 (HRH1), mRNA

0.50

35.

NM_001353

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1;20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (AKR1C1)

0.51


cDNA of Unknown Biological Function


1.

NM_024563.2

Homo sapiens chromosome 5 open reading frame 23 (c5orf23)mRNA

0.48

2.

XM_376189.1

Homo sapiens DKFZP586K1520 protein (DKFZP586K1520), mRNA

0.41

3.

NM_014859.1

Homo sapiens KIAA0672 gene product (KIAA0672), mRNA.

0.28

4.

XM_352945.1

Homo sapiens hypothetical protein FLJ37034 (FLJ37034), mRNA

0.46

5.

NM_138409.1

Homo sapiens chromosome 6 open reading frame 117 (C6orf117), mRNA

0.21


SAM analysis was performed to identify the statistically significant differentially expressed genes. Genes that are common to both platforms are highlighted as Bold and Italics.

Satish et al. BMC Medical Genomics 2008 1:10   doi:10.1186/1755-8794-1-10

Open Data