|
The fitted linear mixed effect models for each biomarker expression within Gleason grade 3+3 tumors, where zone of origin (TZ vs. PZ) was fitted as a fixed effect and patient as a random effect. |
||||
| Marker |
Variable |
Coefficient |
SE |
P-value |
|
|
||||
| Bax |
Intercept |
2.73 |
0.18 |
- |
| TZ (vs. PZ) |
-2.27 |
0.32 |
< 0.0001 |
|
| Bcl-XL |
Intercept |
3.58 |
0.15 |
- |
| TZ (vs. PZ) |
-0.25 |
0.15 |
0.12 |
|
| Bin1 |
Intercept |
2.13 |
0.25 |
- |
| TZ (vs. PZ) |
-1.47 |
0.44 |
0.005 |
|
| FAS |
Intercept |
0.27 |
0.22 |
- |
| TZ (vs. PZ) |
-0.20 |
0.39 |
0.61 |
|
| MDM2 |
Intercept |
2.81 |
0.60 |
- |
| TZ (vs. PZ) |
-2.81 |
1.04 |
0.02 |
|
| P21 |
Intercept |
2.67 |
0.28 |
- |
| TZ (vs. PZ) |
-2.13 |
0.49 |
0.0008 |
|
| P65 |
Intercept |
1.67 |
0.37 |
- |
| TZ (vs. PZ) |
-1.67 |
0.63 |
0.02 |
|
McDonnell et al. BMC Medical Genomics 2008 1:1 doi:10.1186/1755-8794-1-1 |
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