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This article is part of the supplement: International Conference for Healthcare and Medical Students 2011

Open Access Oral presentation

Validation of a diabetes risk score in identifying patients at risk of progression to abnormal glucose tolerance post partum

C Crowe1*, E Noctor1, LA Carmody1, B Wickham1, G Avalos1, G Gaffney2, P O’Shea3, F Dunne1 and ATLANTIC DIP Collaborators

  • * Corresponding author: C Crowe

Author Affiliations

1 Department of Medicine, University Hospital Galway and National University of Ireland, Galway, Ireland

2 Department of Obstetrics and Gynaecology, University Hospital Galway, Ireland

3 Department of Clinical Biochemistry, University Hospital Galway, Ireland

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BMC Proceedings 2012, 6(Suppl 4):O36  doi:10.1186/1753-6561-6-S4-O36


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1753-6561/6/S4/O36


Published:9 July 2012

© 2012 Crowe et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Introduction

FINDRISC (Finnish Diabetes Risk Score) is a risk assessment tool widely used for the prediction of the development of type 2 diabetes (T2DM), combining a questionnaire with simple anthropometric measurements to identify patients at risk of developing diabetes, with increasing score (0-26) signifying increased risk. A cut off score of 9 has previously been proposed (with drug-treated DM as the endpoint) with a positive predictive value (PPV) of 0.12 and negative predictive value (NPV) of 0.99, area under receiver operating characteristic curve (AuROC)=0.80. It has been well validated in the general population.

Methods

We examined its use in predicting progression to pre-diabetes/diabetes in a cohort of Caucasian patients with a history of gestational diabetes mellitus (GDM). 116 women with a history of GDM underwent screening 1-5 years post-index pregnancy. Those with a history of persistent post-partum dysglycaemia had fasting glucose levels taken, while others underwent a 75g OGTT.

Results

Of the 116 women with a history of GDM, 83 showed normal glucose tolerance (NGT) post-partum (71.6%). 22 patients had abnormal OGTT at 12 weeks (18.9%). A further 11 patients (9.5%) had pre-diabetes/diabetes at rescreening. The FINDRISC score was higher in patients with pre-diabetes/diabetes than those with NGT post partum (mean score 13.6+/- 4.1 vs. 11.0+/- 3.7, p<0.01). For a cut-off score of 9, PPV was 0.30, NPV was 0.79, AuROC=0.69, comparable with published data in the general population.

Conclusions

This study shows the validity of an inexpensive, convenient risk score in helping to determine which patients may need more frequent screening post GDM.