Table 1

AUCs of pdFIX, CHOrFIX, HEK293rFIX, and high-phospho/sulfo HEK293rFIX in a FIX-knock-out mouse pharmacokinetic study. Only relative AUC values are shown. Statistically significant different ratios to CHOrFIX (at the 5 % level) are marked with an asterisk*. The ratio of HEK293rFIX high phospho/sulfo to HEK293- total rFIX was also statistically significantly different for both antigen and activity.

Relative value of AUC: antigen

Relative value of AUC: clotting activity


pdFIX

1.5*

1.8*

CHOrFIX

1

1

HEK293rFIX high phospho/sulfo

0.7*

0.7*

HEK293rFIX

0.4*

0.4*


Böhm et al. BMC Proceedings 2011 5(Suppl 8):P23   doi:10.1186/1753-6561-5-S8-P23

Open Data