Table 1

SNP significantly associated with immune traits

Complement activity


chromosome

SNP1

Kbps

cM2

Natural Abs

Acquired Abs

classical

alternative


chr 3

rs13526054 (IL17A)3

110370

275.9

+

-

+

+

rs15458146 (IL17A)3

110371

275.9

+

+

-

-


chr 13

rs15677371

7927

19.8

+

-

-

-

rs15677377

7927

19.8

+

-

-

-

rs14050302(IL12B)3

7917

19.8

+

-

-

-

rs14064896 (IRF1)3

17452

43.6

+

-

-

+

rs14064900 (IRF1)3

17452

43.6

-

+

+

-


chr16

snp.gga16Tapasin. 180144exon1TC (TAPBP)3

65

0.2

-

+

+

-

rs15788216 (MHC/BLB1)3

70

0.2

+

+

-

-


chr 26

rs14298900 (IL10)3

2375

5.9

+

-

+

-


1. SNP as present in dbSNP at NCBI (http://www.ncbi.nlm.nih.gov webcite).

2. 1 cM = 4 ยท 105 bps.

3. IL17A, gene encoding interleukin 17A; HTR2C, gene encoding the serotonin receptor 2C; IL12B, gene encoding interleukin 12B; IRF1, gene encoding interferon regulatory transcription factor; MHC, gene encoding major histocompatibility complex; BLB1, gene encoding class II beta chain 1; TAPBP, gene encoding TAP binding protein; IL10, gene encoding interleukin 10.

van der Poel et al. BMC Proceedings 2011 5(Suppl 4):S18   doi:10.1186/1753-6561-5-S4-S18

Open Data