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This article is part of the supplement: Proceedings of the International Symposium on Animal Genomics for Animal Health (AGAH 2010)

Open Access Proceedings

Gene expression pattern in swine neutrophils after lipopolysaccharide exposure: a time course comparison

Gema Sanz-Santos1, Ángeles Jiménez-Marín1, Rocío Bautista2, Noé Fernández2, Gonzalo M Claros2 and Juan J Garrido1*

Author Affiliations

1 Grupo de Genómica y Mejora Animal, Departamento de Genética, Facultad de Veterinaria, Universidad de Córdoba, Campus de Rabanales, Edificio Gregor Mendel C5, 14071 Córdoba, Spain

2 Plataforma Andaluza de Bioinformática, Universidad de Málaga, Edificio de Bioinnovación, C/Severo Ochoa 34, Parque Tecnológico de Andalucía, 29590 Málaga, Spain

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BMC Proceedings 2011, 5(Suppl 4):S11  doi:10.1186/1753-6561-5-S4-S11

Published: 3 June 2011

Additional files

Additional file 1:

IPA Networks Networks are selected if their scores are higher than 25 for each cluster (except for cluster 1, because the number of genes is too small to analyze with IPA). The table contains columns with the network number, the name of the comparison list, names of the genes involved in the network, the score value and the top functions. Focus genes are shown in bold.

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Open Data

Additional file 2:

IPA Biofunctions and Canonical Pathways Top 10 IPA biofunctions and canonical pathways. a) Biofunctions: Tested by the Fisher Exact test p-value. b) Canonical Pathway. For each list, the pathways are ranked by the score [score = -log(p-value)] using the same criterions than biofunctions. The table includes the ratio (number of focus molecules in a given pathway divided by the total number of the molecules that conform that pathway)

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Open Data

Additional file 3:

Network 3 from gene cluster 2 The top functions of this network are Molecular transport, protein trafficking and cellular development. This network is focused on TGFB1 molecule (orange circle). Canonical pathways and functions are overlaid with red and yellow edges, respectively.

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Open Data

Additional file 4:

Network 2 from gene cluster 3 The top functions of this network are Infection mechanism, gene expression, and cell death. This network is focused on NF-κB molecule (purple circle). Canonical pathways and functions are overlaid with red and yellow edges, respectively.

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Open Data