The Genetic Analysis Workshop 16 Problem 3 diagram. Figure 1 shows simulated phenotypes emulating the lipid domain (HDL, LDL, TG, and CHOL) and its contribution to cardiovascular disease risk (CAC and MI). Simulated major genes are symbolized with Greek letters. There are 1,000 polygenes for each trait HDL, LDL, and TG, several of them with pleiotropic effects. Continued lines and arrows show causality/interaction (I); dashed lines show pharmacogenetic effects only for subjects treated with medication, where response was dependent on the subjects' genotypes. Environmental factors such as diet, smoking, and medication were modeled in the simulation.
Kraja et al. BMC Proceedings 2009 3(Suppl 7):S4