This article is part of the supplement: Proceedings of the First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007)
Unraveling genetic regulatory networks of mammalian retroelements
Department of Biochemistry and Molecular Biology & Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
BMC Proceedings 2009, 3(Suppl 2):S3 doi:10.1186/1753-6561-3-S2-S3Published: 10 March 2009
Advances in the science of toxicogenomics have opened the door to major advances in our understanding of the molecular basis of environmental pathogenesis and the role of environmental factors in human disease. This report summarizes major findings in the laboratory defining the molecular basis of L1 retroelement activation in mammalian cells and the architecture of gene regulatory networks involved in phenotypic control.