Table 1

Number of expressions with at least one significant eQTL


Genome-wide significance level (point-wise significance level)



0.05 (4.7 × 10-6)
0.01 (3.2 × 10-7)
0.001 (6.7 × 10-9)

Threshold by Gaussian approximation
4.43
4.98
5.68
Number by chance (95% CI)
177.7 (162.2, 193.2)
35.6 (28.5, 42.6)
3.6 (1.3, 5.8)




Original data
     Threshold by permutation
4.36
4.95
5.68
     Number by permutation (95% CI)
176.0 (139.0, 224.5)
36.0 (24.0, 56.0)
4.0 (0, 9.0)
     Observed number
235
66
24
     Sibship only
173
40
13




Residual data (9p13.3)
     Threshold by permutation
4.45
5.06
5.81
     Number by permutation (95% CI)
180.0 (154.0, 207.0)
36.0 (25.0, 48.0)
4.0 (0, 8.0)
     Observed number
225
87
26




Residual data (14q32)
     Threshold by permutation
4.46
5.07
5.85
     Number by permutation (95% CI)
178.0 (151.5, 205.0)
36.0 (24.0, 47.0)
3 (0, 8.0)
     Observed number
212
70
23