Table 4

Genotype-based associations with R620W and RA sub-type (reference is major allele CC homozygote)

PedGenie 2.1

NARAC Study 1^a

NARAC Study 2^b

Meta-analysis

Previously published^c

RA Phenotype

Genotype

OR

95% CI

p^d

OR

95% CI

p^d

OR

95% CI

p^e

OR

95% CI

p

RF+ vs. Ctrls.

CT or TT

1.80

1.29–2.49

<0.001

2.34

1.82–3.00

<0.001

2.13

1.76–2.57

<0.001

2.36

1.76–3.16

<0.001

RF- vs. Ctrls.

CT or TT

1.40

0.87–2.27

0.20

1.08

0.71–1.65

0.77

1.20

0.87–1.65

0.31

1.17

0.6–2.31

0.64

RF+ vs. RF-

CT or TT

1.07

0.58–2.00

0.79

1.46

0.83–2.56

0.12

1.30

0.86–1.95

0.18

Previously published^f

CCP+ vs. Ctrls.

CT or TT

1.69

1.18–2.41

0.001

2.03

1.57–2.62

<0.001

1.90

1.55–2.34

<0.001

1.49

1.23–1.79

<0.001

CCP- vs. Ctrls.

CT or TT

1.59

1.04–2.45

0.035

1.41

1.03–1.95

0.029

1.47

1.15–1.88

0.001

1.04

0.83–1.29

0.40

CCP+ vs. CCP-

CT or TT

1.05

0.61–1.80

0.93

1.16

0.83–1.60

0.32

1.12

0.84–1.50

0.47

RF or CCP+ vs. RF-/CCP-

CT or TT

1.29

0.65–2.53

0.55

1.43

0.81–2.52

0.06

1.38

0.89–2.13

0.051

1.43

1.16–1.77

<0.001

^aProblem 2 data, 446 family cases and 103 family controls in 202 affected NARAC pedigrees, 664 independent NYC controls; excludes Plenge et al. [6] samples.

^bProblem 2 data, samples in Plenge et al. [6] candidate gene file, 839 family cases in 463 pedigrees and 854 independent NYC controls.

^cBegovich et al. [3] replication sample (NARAC; 463 independent-sib cases, 926 independent controls), CLR analysis.

^dEmpirical confidence intervals and chi-square p-values, 1000 simulations; p < 0.05 in bold.

^eEmpirical confidence intervals and CMH chi-square general association test, 1000 simulations; p < 0.05 in bold.

^fPlenge et al. [6] first clinical collection, Epidemiological Investigation of RA (EIRA) Swedish cohort (2370 cases 1757 controls); allele association.

Curtin et al. BMC Proceedings 2007 1(Suppl 1):S12