Table 1

Nominal value for the parameters and MINLP best solution
Parameter Nominal value MINLP solution
k2 5.18E+07 4.74E+07
k3 9.76E+01 1.20E+02
α 5.79E-02 5.23E-02
ktr 1.00E+03 8.66E+02
ktl 4.96E+03 4.28E+03
ktl2 1.03E+03 1.27E+03
ktl3 2.05E+03 1.64E+03
kz 4.99E+01 6.06E+01
kd2 1.00E+01 1.25E+01
DNA0 6.16E-04 7.08E-04
Ka 1.82E-07 2.11E-07
K 1.00E+03 8.48E+02
kd 1.18E+00 9.55E-01
khy 2.00E+06 1.76E+06
ktransf 9.74E-01 8.07E-01
kdegf 1.36E-01 1.84E-01
khy - -
n1: 3 3
n2: 1 1
n3: 2 3
n4: 3 3
n5: 0 0
bin1: 1 1
bin2: 1 1
bin3: 0 0

The bounds for the real parameters were taken at 50% and 200% around the initial values and for the integers they are based on the typical values of Hill coefficients, from 0 to 3. The value of parameter khy is not reported because it is inactive when bin3 = 0.

Rodriguez-Fernandez et al.

Rodriguez-Fernandez et al. BMC Systems Biology 2013 7:76   doi:10.1186/1752-0509-7-76

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