Table 1

Detailed statistics of SignaLink 2
Species C. elegans D. melanogaster H. sapiens
Layers Nodes Edges Nodes Edges Nodes Edges
Pathway members 198 253 210 260 1,150 1,640
Pathway regulators 0 0 0 0 751 2,122
Post-translational modifiers 916 3,072 1,713 6,896 4,682 82,852
Directed protein-protein interactors 49 47 128 171 951 3,252
Undirected protein-protein interactors 100 245 166 496 1,387 6,086
TF regulators 152 187 998 16,319 2,585 30,736
miRNA regulators 806 9,658 939 5,308 2,844 245,857
TFs of miRNAs 25 19 0 0 716 5,209

SignaLink 2 contains different amounts of proteins/miRNAs in each layer in each species, according to the data from the literature and external sources. See the main text for details on the layers and sources. For C. elegans and D. melanogaster, no data was available for pathway regulator scaffold proteins and for TFs that regulate miRNAs.

Fazekas et al.

Fazekas et al. BMC Systems Biology 2013 7:7   doi:10.1186/1752-0509-7-7

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