Additional file 2.

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Video S1. Movie of the stochastic simulation. Movie of the stochastic simulation for the lux02 operon, 10 h of induction at <a onClick="popup('http://www.biomedcentral.com/1752-0509/7/6/mathml/M3','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/7/6/mathml/M3">View MathML</a>, burst size bR=bI=4. Cells are modelled as individual compartments containing a copy of the LuxR/LuxI regulatory network. The Gillespie algorithm (see text for details) is used to integrate the stochastic dynamics of the whole system of cells. Cell growth and division is explicitly taken into account as well as a certain degree of stochasticity in the cell cycle duration. Cells movement is purely aesthetic since we do not include any spatial effects in our model and consider a well-mixed environment. The number of cells (N=100) is maintained constant by removing one cell at random each time a cell divides.

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Weber and Buceta BMC Systems Biology 2013 7:6   doi:10.1186/1752-0509-7-6