Figure 3.

Response curves to autoinducer induction in the population-average model.lux01 (A) and lux02 (B) operons. The normalized GFP concentration is plotted as a function of the exogenous autoinducer concentration <a onClick="popup('http://www.biomedcentral.com/1752-0509/7/6/mathml/M34','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/7/6/mathml/M34">View MathML</a>: steady-state response for increasing (arrow-free upper blue curve) and decreasing (arrow-free red curve) autoinducer concentration, response under 10 h induction time for increasing (blue curve with arrow) autoinducer concentration, transient response after 2 hours of induction (lower blue curve) from initially non-induced cells, decreasing-concentration trajectories (green curves) for cells weakly induced (2 hours) at <a onClick="popup('http://www.biomedcentral.com/1752-0509/7/6/mathml/M35','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/7/6/mathml/M35">View MathML</a>, 75 nM and 50 nM, and decreasing-concentration trajectories (red curve with arrow) for cells fully induced (10 hours) at <a onClick="popup('http://www.biomedcentral.com/1752-0509/7/6/mathml/M36','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/7/6/mathml/M36">View MathML</a>. The decreasing-concentration trajectories reduce the value of <a onClick="popup('http://www.biomedcentral.com/1752-0509/7/6/mathml/M37','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/7/6/mathml/M37">View MathML</a> hourly by 25% (similar to the experiments in [10]). The gray-shaded region between the increasing and decreasing steady-state curves reveals bistability in the range <a onClick="popup('http://www.biomedcentral.com/1752-0509/7/6/mathml/M38','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/7/6/mathml/M38">View MathML</a> (lux01) and <a onClick="popup('http://www.biomedcentral.com/1752-0509/7/6/mathml/M39','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/7/6/mathml/M39">View MathML</a> (lux02).

Weber and Buceta BMC Systems Biology 2013 7:6   doi:10.1186/1752-0509-7-6
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