|Synthetic lethality induced by elimination of phosphorylation/dephosphorylation reactions|
|Eliminated reaction||Impacted single mutation strains that are|
|viable (inviable) before (after) perturbation|
|Whi5 phosphorylationby Bck2||cln3 Δ, Multicopy BCK2, cdh1 Δ, sic1 Δ, swi5 Δ,|
|CLB5-db Δ, net1-ts, GAL-CLB2, APC-A|
|CKI phosphorylation by Cln2||bck2 Δ, GAL-SIC1, net1-ts, APC-A|
|CKI phosphorylation by Clb2||GAL-CLN3, cdh1 Δ, GAL-CLB5, CLB1 clb2 Δ|
|CKI dephosphorylation by Cdc14||bck2 Δ, cdh1 Δ, GAL-CLB2, APC-A|
|Whi5 phosphorylation by Cln3||bck2 Δ, cdh1 Δ, APC-A|
|SBF phosphorylation by Clb2||cdh1 Δ, CLB5-db Δ, APC-A|
|Whi5 phosphorylation by Cln2||bck2 Δ,APC-A|
|Whi5 dephosphorylation by Cdc14||APC-A|
|Net1 dephosphorylation by PPX||Multicopy CDC15|
Upon setting phosphorylation/dephosphorylation rate constants to zero (left column), viability is lost in several single mutation strains (right column).
Oguz et al.
Oguz et al. BMC Systems Biology 2013 7:53 doi:10.1186/1752-0509-7-53