Table 3

The 20 most fragile phenotypes
Strain name Phenotype Percent of total losses
CLB2-db Δ multicopy SIC1 Viable 3.38
cln1 Δ cln2 Δ cdh1 Δ Viable 3.19
CLB2-db Δ clb5 Δ clb6 Δ in galactose Viable 3.16
cdc15 Δ net1-ts cdh1 Δ Viable 2.85
GAL-CLB2 cdh1 Δ Inviable 2.84
cln1 Δ cln2 Δ cdh1 Δ GAL-CLN2 Viable 2.74
CLB2-db Δ in galactose Inviable 2.70
APC-A Viable 2.40
APC-A sic1 Δ Viable 2.39
CLB5-db Δ pds1 Δ Viable 2.35
APC-A cdh1 Δ multicopy SIC1 Viable 2.31
cdh1 Δ Viable 2.24
cln1 Δ cln2 Δ cln3 Δ sic Δ Viable 2.03
bck2 Δ Viable 1.93
GALL-CDC20 sic1 Δ cdh1 Δ Viable 1.84
APC-A cdh1 Δ in galactose Inviable 1.72
clb5 Δ clb6 Δ cdc20 Δ pds1 Δ Viable 1.69
cln3 Δ bck2 Δ sic Δ Inviable 1.67
cln1 Δ cln2 Δ Viable 1.54
APC-A sic1 Δ cdc6 Δ2-49 Viable 1.53

These are the phenotypes that are most often lost (i.e., incorrectly simulated) when perturbations are applied to individual model parameters. Fragility decreases from top to bottom.

Oguz et al.

Oguz et al. BMC Systems Biology 2013 7:53   doi:10.1186/1752-0509-7-53

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