Effects of population size and criterion used in LH sampling on the optimization. Increase in the number of mutants captured during independent DE runs for population sizes N = 19 (green lines) and N = 27 (blue lines). Pink line: Model performance for the initial guess for the parameter vector (O = 72 hits; Omax = 119). Red line: WT viability in glucose is not enforced during LH sampling phase.
Oguz et al. BMC Systems Biology 2013 7:53 doi:10.1186/1752-0509-7-53