Overview of the hypergraph-based model for constructing higher-order miRNA-mRNA interaction networks at a specific cancer stage. Solid and dotted circles denote miRNAs and mRNAs, respectively. Closed curves denote hyperedges (i.e. modules). In the conventional graph representation (two graphs in the right-bottom of the central box of the figure), ellipses and boxes denote miRNAs and mRNAs, respectively. Grey and white indicate respective high and low gene expression levels.
Kim et al. BMC Systems Biology 2013 7:47 doi:10.1186/1752-0509-7-47