Figure 7.

Simulation analyses of positive feedback loop of Ime2. A) Ime1 and Ime2 dynamics when varying s’ime2, the maximum rate of auto-regulation-dependent Ime2 synthesis. Red curve: s’ime2 = 0 (deleting the feedback loop); cyan curve: s’ime2 = 0.3 (decreasing the feedback loop); blue curve: s’ime2 = 30 (increasing the feedback loop); green curve: s’ime2 = 3 (baseline value). B) Ime1 and Ime2 dynamics when varying c2, the constant measuring half- maximum activation of Ime2 synthesis through auto-regulation. Red curve: c2 = ∞ (deleting the feedback loop); cyan curve: c2 = 14 (decreasing the feedback loop); blue curve: c2 = 0.14 (increasing the feedback loop); green curve: c2 = 1.4 (baseline value). C) Ime1 and Ime2 dynamics when varying s’ime2 and c2 simultaneously. Red curve: s’ime2 = 0 and c2 = ∞ (deleting the feedback loop); cyan curve: s’ime2 = 0.3 and c2 = 14 (decreasing the feedback loop); blue curve: s’ime2 = 30 and c2 = 0.14 (increasing the feedback loop); green curve: s’ime2 = 3 and c2 = 1.4 (baseline value). The mathematical model of the feedback knockout is described in Additional file 2: Table S8.

Ray et al. BMC Systems Biology 2013 7:37   doi:10.1186/1752-0509-7-37
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