Figure 6.

Simulation analyses of negative feedback loop from Ime2 to Ime1. A) Ime1 and Ime2 dynamics when varying d’ime1, the maximum rate of Ime2-activated Ime1 degradation. Red curve: d’ime1 = 0 (deleting the feedback loop); cyan curve: d’ime1 = 0.1 (decreasing the feedback loop); blue curve: d’ime1 = 10 (increasing the feedback loop); green curve: d’ime1 = 1 (baseline value). B) Ime1 and Ime2 dynamics when varying c1, the constant measuring half-maximum activation of Ime1 degradation by Ime2. Red curve: c1 = ∞ (deleting the feedback loop); cyan curve: c1 = 0.1 (decreasing the feedback loop); blue curve: c1 = 0.001 (increasing the feedback loop); green curve: c1 = 0.01 (baseline value). C) Ime1 and Ime2 dynamics when varying d’ime1 and c1 simultaneously. Red curve: d’ime1 = 0 and c1 = ∞ (deleting the feedback loop); cyan curve: d’ime1 = 0.1 and c1 = 0.1 (decreasing the feedback loop); blue curve: d’ime1 = 10 and c1 = 0.001 (increasing the feedback loop); green curve: d’ime1 = 1 and c1 = 0.01 (baseline value). The mathematical model of the feedback knockout is described in Additional file 2: Table S7.

Ray et al. BMC Systems Biology 2013 7:37   doi:10.1186/1752-0509-7-37
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