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Open Access Highly Accessed Research article

Model composition through model reduction: a combined model of CD95 and NF-κB signaling pathways

Elena Kutumova12*, Andrei Zinovyev345, Ruslan Sharipov16 and Fedor Kolpakov12

Author Affiliations

1 Institute of Systems Biology, Ltd, 15 Detskiy proezd, Novosibirsk 630090 Russia

2 Design Technological Institute of Digital Techniques, The Siberian Branch of The Russian Academy of Sciences, 6 Acad. Rzhanov Str, Novosibirsk 630090 Russia

3 Institut Curie, 26 rue d’Ulm, F-75248 Paris, France

4 INSERM U900, Paris F-75248 France

5 Mines ParisTech, Fontainebleau F-77300 France

6 Institute of Cytology and Genetics, The Siberian Branch of The Russian Academy of Sciences, 10 Acad. Lavrentyev Ave, Novosibirsk 630090 Russia

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BMC Systems Biology 2013, 7:13  doi:10.1186/1752-0509-7-13

Published: 15 February 2013

Additional files

Additional file 1: Table 1S:

Notations of parameters used in the paper and in the original models. Table 2S. Table of all reactions (excepting degradation) and rate constants in the composite model. Table 3S. Table of degraded species and kinetic laws of degradation in the composite model. Table 4S. Table of nonzero initial concentrations in the composite model. Table 5S. Steady state analysis of the Bentele’s model and the composite model. Species. Table 6S. Steady state analysis of the Neumann’s model and the composite model, Table 7S. Calculation of the mean sensitivity for the investigated apoptosis models. Table 8S. Analysis of predictions regarding apoptosis in HeLa cells as formulated by Neumann et al. Table 9S. Predictions of the models for SKW 6.4 cells. Table 10S. Parametric constraints of the models by Bentele et al. and Neumann et al.

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