Net ANLS flux (left) and relative cell glucose uptake (right) versus the velocity of the Glu/Gln cycle. Independently of the correlation between νLAC(a → n) and glucose partitioning observed in Figure 5, neither variable shows significant correlation with the activation level. This results from the absence of constraints imposed by stoichiometry on the rate of neurotransmission (hence on the glutamate-glutamine cycle), the latter being compatible with a large set of solutions relative to glucose partitioning and lactate shuttling.
Massucci et al. BMC Systems Biology 2013 7:103 doi:10.1186/1752-0509-7-103