Resolution:
## Figure 4.
Computed average rate of the glutamate-glutamine cycle versus average OGI. Simulations show that the average V_{cyc} increases as the average OGI decreases, consistently with the underlying relationship
between OGI and glucose uptake. The curves represent conditional averages, computed
over solutions characterized respectively by V_{cyc} ≥ 0, and V_{cyc} > 0. The red dashed line identifies the awake resting state (OGI = 5.5). The crossing
points between the line at OGI = 5.5 and each of the two curves identify the values
of V_{cyc} relevant for the basal conditions. Specifically, V_{cyc} is roughly 0.06 or 0.08 for the groups V_{cyc} ≥ 0 and V_{cyc} > 0, respectively. The two curves are significantly different for OGI . This is consistent with the fact that the contribution of solutions with V_{cyc} = 0 becomes negligible at high activation levels.
Massucci |