Change of distribution in the tissue-specific networks by paralogous expansion. The ratio of the respective degrees in the expanded tissue-specific networks (eTTNs) to those in the TTNs is shown for the individual tissues. The out-degree of TF genes changed moderately by the expansion in a nearly identical manner across all tissues (about 1.6-fold; yellow squares). In contrast, the in-degree increased considerably (about 2.3-fold), again similarly in all eTTNs (yellow dots). In general, the in-degree of non-TF genes increased slightly more, but with outliers for spleen (below) and testis (above the average; blue dots).
Haubrock et al. BMC Systems Biology 2012 6(Suppl 2):S15 doi:10.1186/1752-0509-6-S2-S15