Tissue distribution of the TFs in the tissue-specific transcriptional networks (TTNs) and the corresponding expanded networks (eTTNs). Shown are the portions of TF genes that appear in the indicated numbers of tissue-specific networks. The majority of TFs in the tissue-specific transcriptional networks (TTFs) that were derived from the RTN are expressed in many, if not all tissues studied (blue bars). In contrast, the newly added TF paralogs in the expanded TTNs (eTTNs) show a much more tissue-specific behaviour in being expressed in only one or few tissues (yellow bars).
Haubrock et al. BMC Systems Biology 2012 6(Suppl 2):S15 doi:10.1186/1752-0509-6-S2-S15