Table 1

The proportions of enhancers that underwent selection based on mouse-rat alignments (neutral reference: fourfold degenerate sites)

Total

Under selectiona

Positively selectedb

Under selectiona/Total

Positively selectedb/Under selectiona

Positively selectedb/Total


HT

2554

875

360

34.25%

41.14%

14.09%

FB

1253

595

67

47.48%

11.26%

5.34%

MB

1311

521

101

39.74%

19.38%

7.70%

LB

2570

1037

212

40.35%

20.44%

8.24%


FB: forebrain; MB: midbrain; LB: limb; HT: heart.

aA significantly unequal proportion of substituted sites were observed between enhancers and the fourfold degenerate sites of the neighboring gene by Fisher's exact test.

bEnhancers that underwent selection and had a higher substitution rate than the fourfold degenerate sites of the neighboring gene.

Liao and Weng BMC Systems Biology 2012 6(Suppl 2):S1   doi:10.1186/1752-0509-6-S2-S1

Open Data