Additional file 5.

Supplementary figure S3. Enhancers with a highly expressed adjacent gene evolve more rapidly. Evolutionary rates are represented by D (A) or D/d4 (B). Gene expression level was defined by the maximum expression signal of the 61 mouse tissues. Spearman's rank correlation coefficient is (C) 0.044 (P <10-4) and (F) 0.042 (P <10-3) for the unbinned data. The values of upper quartile, median, and lower quartile are indicated in each box, whereas the bars outside the box indicate semi-quartile ranges. Pairwise comparisons showing significant differences in D or D/d4 are connected with gray lines (*0.01<P≦0.05 and ***P≦0.001 by Mann-Whitney U test).

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Liao and Weng BMC Systems Biology 2012 6(Suppl 2):S1   doi:10.1186/1752-0509-6-S2-S1