Bifurcation plot for the steady state of TF-A on the control parameter of transcription rate kf. The system in the region (i.e., 5.45 < kf <6.68) exhibits bistability. The other parameters are fixed as dissociation constant of TF-A dimer from TF-REs Kd = 10, the degradation constant kd = 1, and the basal rate of TF-A synthesis Rbas = 0.4.
Wang et al. BMC Systems Biology 2012 6(Suppl 1):S9 doi:10.1186/1752-0509-6-S1-S9