Table 4

Enriched KEGG pathway of mouse cBIP and sBIP gene classes.

KEGG pathway ID

Pathway Name

p-value

gene type


mmu03040*

Spliceosome

3.30E-03

cBIP

mmu04110

Cell cycle

3.70E-03

cBIP

mmu04142

Lysosome

4.13E-03

cBIP

mmu03018*

RNA degradation

5.70E-03

cBIP

mmu00970

Aminoacyl-tRNA biosynthesis

8.74E-03

cBIP

mmu03020*

RNA polymerase

8.97E-03

cBIP

mmu00190

Oxidative phosphorylation

1.07E-02

cBIP

mmu03440#

Homologous recombination

1.36E-02

cBIP

mmu00052

Galactose metabolism

1.59E-02

cBIP

mmu05012

Parkinson's disease

1.98E-02

cBIP

mmu04146

Peroxisome

3.03E-02

cBIP

mmu03420#

Nucleotide excision repair

3.30E-02

cBIP

mmu00240

Pyrimidine metabolism

6.22E-03

sBIP

mmu03020*

RNA polymerase

5.15E-03

sBIP

mmu00062

Fatty acid elongation in mitochondria

1.10E-02

sBIP

mmu00903

Limonene and pinene degradation

1.40E-02

sBIP

mmu00280

Valine, leucine and isoleucine degradation

1.98E-02

sBIP

mmu05340

Primary immunodeficiency

4.08E-02

sBIP

mmu00860

Porphyrin and chlorophyll metabolism

4.96E-02

sBIP


The two catteries of mouse bidirectional genes (cBIP, sBIP) were computed for the KEGG pathway enrichment respectively. cBIP represents the genes regulated by the human-mouse conserved bidirectional promoters, while the sBIP represents the genes in the species-specific bidirectional gene pairs. * Transcription and translation related pathways # DNA repair related pathways

Xu et al. BMC Systems Biology 2012 6(Suppl 1):S21   doi:10.1186/1752-0509-6-S1-S21

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