Table 3

Enriched KEGG pathway of human cBIP and sBIP gene classes.

KEGG pathway ID

Pathway Name

p-value

gene type


hsa03040*

Spliceosome

4.24E-04

cBIP

hsa03020*

RNA polymerase

1.09E-03

cBIP

hsa05012

Parkinson's disease

1.64E-03

cBIP

hsa05010

Alzheimer's disease

1.78E-03

cBIP

hsa00190

Oxidative phosphorylation

1.93E-03

cBIP

hsa03018*

RNA degradation

1.93E-03

cBIP

hsa04110

Cell cycle

3.01E-03

cBIP

hsa04142

Lysosome

4.32E-03

cBIP

hsa05016

Huntington's disease

5.11E-03

cBIP

hsa00970

Aminoacyl-tRNA biosynthesis

8.60E-03

cBIP

hsa00052

Galactose metabolism

1.54E-02

cBIP

hsa03440#

Homologous recombination

2.10E-02

cBIP

hsa04146

Peroxisome

3.62E-02

cBIP

hsa03420#

Nucleotide excision repair

4.03E-02

cBIP

hsa00230

Purine metabolism

4.32E-02

cBIP

hsa03410#

Base excision repair

4.47E-02

cBIP

hsa00240

Pyrimidine metabolism

2.28E-02

sBIP

hsa00562

Inositol phosphate metabolism

2.36E-02

sBIP

hsa01100

Metabolic pathways

9.65E-03

sBIP

hsa03020*

RNA polymerase

9.05E-03

sBIP

hsa03030

DNA replication

1.92E-02

sBIP

hsa03050

Proteasome

4.85E-02

sBIP

hsa03410#

Base excision repair

1.58E-02

sBIP

hsa03420#

Nucleotide excision repair

3.70E-02

sBIP

hsa04115

p53 signaling pathway

4.81E-02

sBIP

hsa05215

Prostate cancer

4.30E-02

sBIP


The two categeries of human bidirectional genes (cBIP, sBIP) were computed for the KEGG pathway enrichment respectively. cBIP represents the genes regulated by the human-mouse conserved bidirectional promoters, while the sBIP represents the genes in the species-specific bidirectional gene pairs. * Transcription and translation related pathways. # DNA repair related pathways

Xu et al. BMC Systems Biology 2012 6(Suppl 1):S21   doi:10.1186/1752-0509-6-S1-S21

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