Table 3 |
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|
Enriched KEGG pathway of human cBIP and sBIP gene classes. |
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|
KEGG pathway ID |
Pathway Name |
p-value |
gene type |
|
|
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|
hsa03040* |
Spliceosome |
4.24E-04 |
cBIP |
|
hsa03020* |
RNA polymerase |
1.09E-03 |
cBIP |
|
hsa05012 |
Parkinson's disease |
1.64E-03 |
cBIP |
|
hsa05010 |
Alzheimer's disease |
1.78E-03 |
cBIP |
|
hsa00190 |
Oxidative phosphorylation |
1.93E-03 |
cBIP |
|
hsa03018* |
RNA degradation |
1.93E-03 |
cBIP |
|
hsa04110 |
Cell cycle |
3.01E-03 |
cBIP |
|
hsa04142 |
Lysosome |
4.32E-03 |
cBIP |
|
hsa05016 |
Huntington's disease |
5.11E-03 |
cBIP |
|
hsa00970 |
Aminoacyl-tRNA biosynthesis |
8.60E-03 |
cBIP |
|
hsa00052 |
Galactose metabolism |
1.54E-02 |
cBIP |
|
hsa03440# |
Homologous recombination |
2.10E-02 |
cBIP |
|
hsa04146 |
Peroxisome |
3.62E-02 |
cBIP |
|
hsa03420# |
Nucleotide excision repair |
4.03E-02 |
cBIP |
|
hsa00230 |
Purine metabolism |
4.32E-02 |
cBIP |
|
hsa03410# |
Base excision repair |
4.47E-02 |
cBIP |
|
hsa00240 |
Pyrimidine metabolism |
2.28E-02 |
sBIP |
|
hsa00562 |
Inositol phosphate metabolism |
2.36E-02 |
sBIP |
|
hsa01100 |
Metabolic pathways |
9.65E-03 |
sBIP |
|
hsa03020* |
RNA polymerase |
9.05E-03 |
sBIP |
|
hsa03030 |
DNA replication |
1.92E-02 |
sBIP |
|
hsa03050 |
Proteasome |
4.85E-02 |
sBIP |
|
hsa03410# |
Base excision repair |
1.58E-02 |
sBIP |
|
hsa03420# |
Nucleotide excision repair |
3.70E-02 |
sBIP |
|
hsa04115 |
p53 signaling pathway |
4.81E-02 |
sBIP |
|
hsa05215 |
Prostate cancer |
4.30E-02 |
sBIP |
|
|
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|
The two categeries of human bidirectional genes (cBIP, sBIP) were computed for the KEGG pathway enrichment respectively. cBIP represents the genes regulated by the human-mouse conserved bidirectional promoters, while the sBIP represents the genes in the species-specific bidirectional gene pairs. * Transcription and translation related pathways. # DNA repair related pathways |
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|
Xu et al. BMC Systems Biology 2012 6(Suppl 1):S21 doi:10.1186/1752-0509-6-S1-S21 |
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