Additional file 1.

The metabolite-centric and enzyme-centric views of the E. coli central carbon metabolic network. The file is in the format of *.png, with figures included showing the metabolite-centric (Page 1) and enzyme-centric metabolic (Page 2) networks. In the metabolite-centric view, enzymes/reactions are abbreviated as symbols and denoted by rectangles; metabolites are also abbreviations; inhibitors/activators are drawn as circles beside the reactions. Synth1 is a lumped reaction for synthesizing chorismate and murine; Synth2 is lumped reaction for synthesizing isoleucine, alanine, ketoisovalerate, and diaminopimelate [5]. In the enzyme-centric view, enzymes are denoted by circles and arrows indicate interactions. For more detailed information, see the "Methods" section and Additional file 6.

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Li and Liu BMC Systems Biology 2012 6(Suppl 1):S11   doi:10.1186/1752-0509-6-S1-S11