System state fluctuations caused by enzyme deletions. The impacts of enzyme deletions on system states are shown. In all subfigures, x-axis: state variable (metabolite) indexes (denoted as "Metab", see Additional file 6 for details); y-axis: distance of state variable from the deleted enzyme ("Dist"); z-axis: the impact amplitude ("Amp"). (A - D) The influences of TKb, PGK, TIS, and PGI deletions on system state, respectively. The figures exemplify that an enzyme can affect distant metabolites even greater than its closest neighbours.
Li and Liu BMC Systems Biology 2012 6(Suppl 1):S11 doi:10.1186/1752-0509-6-S1-S11