Additional file 1.
Figure S1. Steady state analysis of the stem cell circuit as functions of LIF and I3concentrations. The dashed lines indicate unstable states. (A) The steady state values of NANOG, OCT4-SOX2 and G as functions of LIF concentration. The plots display two states of the cell. (i) the stem cell state – high OCT4-SOX2/NANOG and low G and (ii) the differentiated state with low OCT4-SOX2/NANOG and high G (B) Similar graphs for small molecule differentiation inhibitors I3 concentration (here for 100). Although there are still two states, NANOG is still higher here than in the previous case. Shown also is the level of FGF4 (magenta), which is at ≃20, which is much lower than in the previous case.
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Chickarmane et al. BMC Systems Biology 2012 6:98 doi:10.1186/1752-0509-6-98