Figure 4.

Visualization of the flow of data generated by laboratory scientists through The Cell Collective Knowledge Base and Bio-Logic Builder. For example scientists A and B identify different upstream regulators (protein X and Y , respectively) of protein Z. This knowledge is subsequently recorded in the Upstream Regulators section on the page of protein Z. Then both scientists A and B determine what the relationship is between the two upstream regulators of Z. Once the overall regulation mechanism is agreed upon, the scientists use Bio-Logic Builder to add the regulatory mechanism of Z to an actual model. The mathematical representation of the species bio-logic is generated in the background, so the user never has to define any mathematical equations nor expressions.

Helikar et al. BMC Systems Biology 2012 6:96   doi:10.1186/1752-0509-6-96
Download authors' original image