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Open Access Research article

A reaction–diffusion mechanism influences cell lineage progression as a basis for formation, regeneration, and stability of intestinal crypts

Lei Zhang134, Arthur D Lander234 and Qing Nie134*

Author Affiliations

1 Department of Mathematics, University of California, Irvine, CA, 92697, USA

2 Department of Development and Cell Biology, University of California, Irvine, CA, 92697, USA

3 Center for Complex Biological Systems, University of California, Irvine, CA, 92697, USA

4 Center for Mathematical and Computational Biology, University of California, Irvine, CA, 92697, USA

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BMC Systems Biology 2012, 6:93  doi:10.1186/1752-0509-6-93

Published: 31 July 2012

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Additional file 1:

A Reaction–diffusion Mechanism Influences Cell Lineage Progression as a Basis for Formation, Regeneration, and Stability of Intestinal Crypts. Equations for models, numerical methods, stability analysis, tables of parameters, and supplementary figures.

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