Table 1

Description and range of the parameters varied in the mammalian circadian clock model simulations
Parameter name Unit Description Minimum value Level step size Maximum value
vmB nMh-1 Maximum rate of Bmal1 mRNA degradation 0.02 0.05 0.38
vmC nMh-1 Maximum rate of Cry mRNA degradation 0.95 0.08 1.54
vmP nMh-1 Maximum rate of Per mRNA degradation 0.98 0.16 2.09
vdPCN nMh-1 Maximum rate of degradation of nuclear phosphorylated Per-Cry complex 0.99 0.02 1.14
vdIN nMh-1 Maximum rate of degradation of nuclear Per-Cry-Clock-Bmal1 complex 0.08 0.21 1.52
k1 h-1 Rate constant for entry of the Per-Cry complex into the nucleus 0.08 0.21 1.52
k3 nM-1 h-1 Rate constant for the formation of the Per-Cry complex 0.08 0.21 1.52
k5 h-1 Rate constant for entry of the Bmal1 protein into the nucleus 0.27 0.02 0.41
k7 nM-1 h-1 Rate constant for the formation of the inactive Per-Cry-Clock-Bmal1 complex 0.05 0.13 0.95

Tøndel et al.

Tøndel et al. BMC Systems Biology 2012 6:88   doi:10.1186/1752-0509-6-88

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