Open Access Research article

Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models

Kristin Tøndel1*, Ulf G Indahl1, Arne B Gjuvsland1, Stig W Omholt2 and Harald Martens13

Author Affiliations

1 Centre for Integrative Genetics (CIGENE), Dept. of Mathematical Sciences and Technology, Norwegian University of Life Sciences, P. O. Box 5003, N-1432, Ås, Norway

2 CIGENE, Dept. of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, P. O. Box 5003, N-1432, Ås, Norway

3 Nofima, P. O. Box 210, N-1431, Ås, Norway

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BMC Systems Biology 2012, 6:88  doi:10.1186/1752-0509-6-88

Published: 20 July 2012

Additional files

Additional file 1:

S1. Description of the multivariate metamodelling methodology; S2. Statistics of the global classical and inverse metamodels of the mammalian circadian clock model; S3. Supplementary sensitivity analyses of the mammalian circadian clock model; S4. Results from the method benchmarking. Additional file 1 includes references 578111920212223293435363738404142434445464748495051525354555657.

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