Table 1

Optimisation of the coefficient of variation of phospho-Hsp27 particle numbers

Reactions

Changes

(no constraints)

Changes

(constraints)


complex + MKK6 ↔ complex_MKK6

complex_MKK6 → complex + MKK6P

MKK6_phosphatase + MKK6P ↔ Ppase_MKK6P

~

Ppase_MKK6P → MKK6_phosphatase + MKK6

complex + MKK3 ↔ complex_MKK3

complex_MKK3 → complex + MKK3P

MKK3_phosphatase + MKK3P ↔ Ppase_MKK3P

Ppase_MKK3P → MKK3_phosphatase + MKK3

MKK6P + p38 ↔ MKK6P_p38

MKK6P_p38 → MKK6P + p38P

MKK3P + p38 ↔ MKK3P_p38

MKK3P_p38 → MKK3P + p38P

p38_phosphatase + p38P ↔ Ppase_38P

Ppase_p38P → p38_phosphatase + p38


Optimisation of the coefficient of variation of phospho-Hsp27 particle numbers with regards to all 21 reaction parameters of the listed reactions ([LPS]0 = 1 ng/ml). "Changes (no constraints)" means that the coefficient was optimised without any further constraints, whereas "Changes (constrained)" means that during optimisation the phospho-Hsp27 particle number was constrained in the optimisation to stay below the limit of 4.65 million particles. "⇒" ("⇐") denotes an increase (decrease) in the forward rate and a decrease (increase) in the reverse rate, in case of a reversible reaction. "⇔" means that both forward and reaction rates are increased and "~" means that the optimisation led to no clear change

Pahle et al. BMC Systems Biology 2012 6:86   doi:10.1186/1752-0509-6-86

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