Additional file 1.

This file contains: (1) details regarding the process of merging pairs of points; (2) the estimation procedure for a four-variable branched pathway and results of two cases where fluxes contain more than one variable; and (3) the results of the method for a five-variable system where different levels of artificial noise were added to the time series data and sub-datasets were randomly picked from data generated with ten sets of initial conditions.[24,31-33].

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Chou and Voit BMC Systems Biology 2012 6:84   doi:10.1186/1752-0509-6-84