Estimation of dynamic flux profiles from metabolic time series data
Integrative BioSystems Institute and The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA
BMC Systems Biology 2012, 6:84 doi:10.1186/1752-0509-6-84Published: 9 July 2012
Additional file 1:
This file contains: (1) details regarding the process of merging pairs of points; (2) the estimation procedure for a four-variable branched pathway and results of two cases where fluxes contain more than one variable; and (3) the results of the method for a five-variable system where different levels of artificial noise were added to the time series data and sub-datasets were randomly picked from data generated with ten sets of initial conditions.[24,31-33].
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