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Open Access Highly Accessed Research article

Estimation of dynamic flux profiles from metabolic time series data

I-Chun Chou and Eberhard O Voit*

Author Affiliations

Integrative BioSystems Institute and The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA

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BMC Systems Biology 2012, 6:84  doi:10.1186/1752-0509-6-84

Published: 9 July 2012

Additional files

Additional file 1:

This file contains: (1) details regarding the process of merging pairs of points; (2) the estimation procedure for a four-variable branched pathway and results of two cases where fluxes contain more than one variable; and (3) the results of the method for a five-variable system where different levels of artificial noise were added to the time series data and sub-datasets were randomly picked from data generated with ten sets of initial conditions.[24,31-33].

Format: DOCX Size: 9.3MB Download file

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