Figure 1.

The iterative procedure used to reconstruct the genome-scale metabolic model ofS. platensisC1. The draft of the metabolic network was automatically established using Pathway Tools software. The manual curation was performed based on a combination of Spirulina-related journal publications and biochemical books and databases. Missing reactions in the pathway were manually estimated and filled. Blast program was used in order to find a potential corresponding gene. The accepted network was further studied via a structural analysis and simulation based on the COBRA toolbox [13,14.]

Klanchui et al. BMC Systems Biology 2012 6:71   doi:10.1186/1752-0509-6-71
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