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Open Access Highly Accessed Research article

Combinatorial network of transcriptional regulation and microRNA regulation in human cancer

Hui Yu12, Kang Tu2, Yi-Jie Wang4, Jun-Zhe Mao4, Lu Xie2*, Yuan-Yuan Li2* and Yi-Xue Li123*

Author Affiliations

1 Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, People's Republic of China

2 Shanghai Center for Bioinformation Technology, 100 Qinzhou Road, Shanghai, 200235, People's Republic of China

3 School of Life Science and Biotechnology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China

4 Shanghai High School, 989 Baise Road, Shanghai, 200231, People's Republic of China

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BMC Systems Biology 2012, 6:61  doi:10.1186/1752-0509-6-61

Published: 12 June 2012

Additional files

Additional file 1:

How we compiled TF-to-miRNA regulation relationships for intergenicmiRNAs.

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Additional file 2:

The source codes/R functions for this study.

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Additional file 3:

Table S1The edges of the human cancer combinatorial gene regulation network.

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Additional file 4:

Table S2The vertices of the human cancer combinatorial gene regulation network.

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Additional file 5:

The evaluation of predictability of our linear regression models.

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Additional file 6:

Validation of part of predicted hsa-miR-106b targets by a miRNA-transfection dataset GSE6838.

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Additional file 7:

Table S3. Significantly coordinating regulator pairs from the human cancer combinatorial regulatory network.

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