Additional file 10.

Computing Specificity statistics. The histogram of MASS scores for HYPs comparable to the NF-κB-direct HYP (1 ng/mL TNFα treatment of NHBE cells for 0.5 hour). The top histogram resulted from selecting measurables at random from all measurables (Specificity p-value of 0), and the bottom histogram resulted from selecting measurables with comparable likelihood of modulation (Specificity p-value of 0.072). The solid line indicates the NF-κB-direct HYP MASS score. The Specificity p-value was computed by doubling the total fraction of counts that were greater than this score (the fraction of counts in the red boxes).

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Martin et al. BMC Systems Biology 2012 6:54   doi:10.1186/1752-0509-6-54