HYP scores for CDK inhibitor-treated HCT116 cells. Transcriptomic data from HCT116 colon cancer cells treated with the CDK inhibitor R547 was scored using each scoring method (Strength, GPI, EPI, and MASS) for (a) the NF-κB-direct HYP, (b) the IKK/NF-κB signaling HYP, (c) the TNF HYP, and (d) the E2F1-direct HYP. Error bars represent the 95 % confidence interval as determined by the Uncertainty statistic. Scores that failed the Specificity criterion (Specificity p-value > 0.05; 1000 comparable HYPs) are shaded in gray.
Martin et al. BMC Systems Biology 2012 6:54 doi:10.1186/1752-0509-6-54