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Open Access Highly Accessed Database

AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease

Satoshi Mizuno1, Risa Iijima1, Soichi Ogishima1*, Masataka Kikuchi1, Yukiko Matsuoka23, Samik Ghosh2, Tadashi Miyamoto1, Akinori Miyashita4, Ryozo Kuwano4 and Hiroshi Tanaka1

Author Affiliations

1 Department of Bioinformatics, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8510, Japan

2 Systems Biology Institute, Shirokanedai 5-6-9, Minato-ku, Tokyo, 108-0071, Japan

3 JST ERATO Kawaoka Infection-induced Host Response Network Project, The Institute of Medical Science, University of Tokyo, Bld 2, 4F, 4-6-1 Shirokanedai, Minato, Tokyo, 108-8639, Japan

4 Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan

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BMC Systems Biology 2012, 6:52  doi:10.1186/1752-0509-6-52

Published: 30 May 2012

Abstract

Background

Alzheimer’s disease (AD) is the most common cause of dementia among the elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in the field of AD has not been compiled as a database before.

Description

Here, we have constructed a publicly available pathway map called “AlzPathway” that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built an AD pathway map using CellDesigner. AlzPathway is currently composed of 1347 molecules and 1070 reactions in neuron, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells and their cellular localizations. AlzPathway is available as both the SBML (Systems Biology Markup Language) map for CellDesigner and the high resolution image map. AlzPathway is also available as a web service (online map) based on Payao system, a community-based, collaborative web service platform for pathway model curation, enabling continuous updates by AD researchers.

Conclusions

AlzPathway is the first comprehensive map of intra, inter and extra cellular AD signaling pathways which can enable mechanistic deciphering of AD pathogenesis. The AlzPathway map is accessible at http://alzpathway.org/ webcite.